Method of detecting a nucleic acid encoding a vesicle transport

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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536 231, 536 2431, C12Q 168, C07H 2104

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059811927

ABSTRACT:
The invention provides a human vesicle transport protein (NVTP-1) and polynucleotides which identify and encode NVTP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NVTP-1.

REFERENCES:
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Tellam, J.T., et al., "Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 270: 5857-5863 (1995).
Hata, Y., et al., "A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins", Journal of Biological Chemistry, 270:13022-13028 (1995).
Katagiri, H., et al., "A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells", Journal of Biological Chemistry, 270:4963-4966 (1995).
Fujita, Y., et al., "Phosphorylation of Munc-18
-Sec1/rbSec1 by Protein Kinase C", Journal Biological Chemistry, 271:7265-7268 (1996).
Tellam, J.T., et al., (GI 642025) GenBank Sequence Database (Accession U19520), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 642026).
Riento, K., et al., (GI 1246216) GenBank Sequence Database (Accession L41609), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1246217).
Veerasamy, R., et al., "Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 271:13300-13303 (1996).
Ziegler, S.F., et al. (GI 1480868) GenBank Sequence Database (Accession U63533), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (1996).
Abe, Y. GenBank. Accession #AB002559. (1997).

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