Live recombinant avian vaccine using an avian herpesvirus as vec

Details Live recombinant avian vaccine using an avian herpesvirus as vec Live recombinant avian vaccine using an avian herpesvirus as vec

1995-12-26

1999-11-09

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4242041, 4242291, 4352351, 4353201, 435 691, 435 693, 435 711, C12N 701, A39K 39245, A39K 39295

Patent

active

059809060

ABSTRACT:
The live recombinant avian vaccine comprises, as vector, an avian herpesvirus comprising at least one nucleotide sequence coding for and expressing an antigenic polypeptide of an avian pathogenic agent, inserted into the region lying between the ATG of ORF UL55 and the junction of U.sub.L with the adjacent repeat region, under the control of the CMV immediate early promoter. The vector is preferably chosen from the group consisting of Marek's disease viruses (MDV and HVT), infectious laryngotracheitis virus ILTV and herpes of ducks. A polyvalent vaccine formula comprises at least two vaccines of this type, with different inserted sequences.

REFERENCES:
Nash et al. "the UL55 and Ul56 genes of herpes simplex virus type 1 are not required for viral replication, intrapertioneal virulence or establishment of latency in mice". Virology, vol. 204, pp. 794-798, 1994.
Marshall et al. "plasmid associated effects on test gene expression and marek's disease virus plaque formation during recombination trials". Journal of Virological Methods. vol. 40, pp. 195-204, 1992.
Jagadish et al. "birnavbirus precusor polyprotein is processed in E coli by its own virus encoded polypeptide". Journal of Virology. vol. 62, No. 3, pp. 1048-1087, Mar. 1988.
Bradley et al. "loss of Marek's disease virus tumorgenicity is associated with the truncation od RNAs transcribed with BamHI-H". Journal of Virology. vol. 63, No. 10, pp. 4129-4135, Oct. 1989.
Isfort et al. "integration of multiple chicken retroviruses into multiple chicken herpesviruses: herpesviral gD as a common target of intergration". Virology. vol. 203, pp. 125-133, 1994.
Buckmaster et al. "gene sequence and mapping data from Marek's disease virus Herpesvirus of turkey: implications for herpesvirus classification". Journal General Virology. vol. 69, pp. 2033-2042, 1988.
Harty et al. "transcriptional and translational analysis of the UL2 gene of equine herpesvirus 1: a homolog of UL55 of herpes simplex virus type 1 that is maintained in the genome of defective interfering particles". Journal of Virology. vol. 67, No. 4, p, Apr. 1993.
Igarashi et al. "restriction enzyme map of herpesvirus of turkey DNA and its collinear relationship with Marek's disease virus DNA". Virology. vol. 157, pp. 351-358, 1987.
Sinclair et al. "charaterization of a herpes simplex virus type 1 deletion variant (1703) which under-produces vmw63 during immediate early conditions of infection". Journal General Virology. vol. 75, pp. 1083-1089, 1994.

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