Process for preparing carbapenem compounds

Details Process for preparing carbapenem compounds Process for preparing carbapenem compounds

1986-05-02

1987-11-17

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 3140

Patent

active

047075473

ABSTRACT:
Disclosed are 6- and 6,6-disubstituted-3-substituted amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, independently selected from the group consisting of hydrogen, substituted and unsubstituted: alkyl, aryl, and aralkyl; and R' and R" are independently selected from the group consisting of: H, substituted and unsubstituted alkyl and aralkyl, or together form a substituted or unsubstituted cyclic group.
Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4217453 (1980-08-01), Christensen et al.
patent: 4424230 (1984-01-01), Christensen et al.
patent: 4530841 (1985-07-01), Christensen et al.
"Organic Chemistry" by Donald J. Cram & George S. Hammond, McGraw Hill, 1964 pp. 241, 242, 274, 352, 380 & 381.

Affiliated with

Also associated with

Rating

Process for preparing carbapenem compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing carbapenem compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing carbapenem compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1450943