Treatment of chronic inflammatory disorders of the gastrointesti

Details Treatment of chronic inflammatory disorders of the gastrointesti Treatment of chronic inflammatory disorders of the gastrointesti

1997-10-21

1999-01-26

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3158

Patent

active

058639101

ABSTRACT:
The present disclosure relates to an oral formulation for treating gastrointestinal inflammation that includes an effective amount of budesonide suspended in an edible oil, typically a vegetable oil. A method for treating gastrointestinal inflammation in mammals is also described and includes orally administering a composition of this invention to a mammal. In one embodiment, an initial dosage is administered daily for about two to four weeks and the dosage is subsequently tapered, generally at about two week intervals, in response to a reduction in symptoms until a minimum dose that controls symptoms is achieved.

REFERENCES:
patent: 5674860 (1997-10-01), Carling et al.
Gennaro et al., eds., "Capsules", Remington's Pharmaceutical Sciences, 18th ed., 1658-1664 (1990).
Greenberg et al., "Oral Budesonide for Active Crohn's Disease", The New England Journal of Medicine, 331(13) : 836-841 (1994).
Lofberg et al., "Budesonide versus prednisolone retention enemas in active distal ulcerative colitis", Alimentary Pharmacology and Therapeutics, 8 (6) :623-629 (1994).
Reynolds and Hunter, "Pharmacotheraphy of Imflammatory Bowel Disease", Dig. Dis., 11:334-342 (1993).
Rutgeerts et al., "A Comparison of Budesonide with Prednisolone for Active Crohn's Disease", The New England Journal of Medicine, 331(13) :842-845 (1994).
Spencer and McTavish, "Budesonide: A Review of its Pharmacological Properties and Tharapeutic Efficacy in Inflammatory Bowel Disease", Drugs, 50 (5) :854-872 (1995).
Ishihara, Biological Abstracts, vol. 72, No. 6, abstract No. 40363, 1981.

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