Method of radioactively labeling diagnostic and therapeutic agen

Details Method of radioactively labeling diagnostic and therapeutic agen Method of radioactively labeling diagnostic and therapeutic agen

1984-01-30

1987-11-17

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 85, 424 88, 424 89, 424 92, 530350, 530402, 530403, 530405, 530406, 536 11, 536 26, 536 27, 536 28, A61K 4300, A61K 4902

Patent

active

047073527

ABSTRACT:
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable of chelating with the radioactive metal ion, with an ion transfer material having the radioactive metal ion bound thereto and having a binding affinity for the radioactive metal less than the binding affinity of the chelating portion for the radioactive metal ion, wherein prior to contacting the chelating portion is unchelated or is chelated with a second metal having a binding affinity with the chelating portion less than the binding affinity of the radioactive metal ion, whereby a radiolabeled therapeutic or diagnostic agent is formed by the contacting, and separating the radiolabeled therapeutic or diagnostic agent from the ion transfer material, is disclosed along with various components and kits useful in practicing this method and several variations thereof.

REFERENCES:
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patent: 4043998 (1977-08-01), Meares et al.
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patent: 4272503 (1981-06-01), Camin et al.
patent: 4305922 (1981-12-01), Rhodes
Meares et al., Proc. Nat. Acad. Sci. USA, 69, 3718-3722 (1972).
DeRiemer et al., J. Med. Chem., 22, 1019-1023 (1979).

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