Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1982-06-20
1985-10-01
Sneed, Helen M. S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
514494, 514844, C01F 306
Patent
active
045447616
DESCRIPTION:
BRIEF SUMMARY
INTRODUCTION
This invention relates to certain pharmaceutical compounds and to their use for therapeutic and prophylactic treatment of the human body and for veterinary purposes.
More particularly the invention relates to use of metal glycerolate compounds as a base for the therapeutic and prophylactic treatment of certain skin disorders and irritations, and also for internal as well as external use. The use of the compounds also extends for use as a base for cosmetic preparations.
It is well known that at least several trace elements are required for cell division and tissue repair and for other bodily processes but there has always been the problem of finding a method of applying or supplying trace elements to the required point in a usable form and at the same time with negligible systemic toxicity.
In particular the metal zinc is necessary in trace element form for cell division and tissue repair and also in various compounds has a known slight bactericidal and fungicidal action on the skin and once again the problem is to apply the metal to the required site in a usable form.
Crystalline glycerato-metal complexes were first described in a paper in the Australian Journal of Chemistry volume 23, 1970, Page 1,963 and in that paper the method of forming these compounds and some of their physical properties are given. These compounds form during the heating of particular metal oxides, hydroxides or salts with glycerol at temperatures around 120.degree. or higher.
The physical structure of the resulting chelated compounds generally produces a platy morphology resulting in a talc-like or slippery tactile impression.
BASIS OF THE INVENTION
The present applicant has found that the use of glycerato-metal complexes can be arranged to give valuable advantage in the treatment of various medical disorders, and extends to a method of treatment of skin disorders comprising the step of applying to the affected skin a modified zinc glycerolate complex including a pharmaceutically acceptable carrier or extender, or the compound may be used as a barrier substance or a sun screen or as a protective surface of high lubricity when applied to the skin.
According to the present invention advantageous properties of the zinc glycerolate complex are controlled during production to achieve a compound with the required characteristic, and the compound can be subsequently chemically altered by certain reagents to achieve a composition which may recommend its use because of specific effects in particular topical skin application whether for therapeutic or cosmetic purposes while maintaining the advantageous physical properties.
Any zinc salt or compound which decomposes to ZnO on heating at temperatures between approximately 120.degree.-300.degree. C. will form this compound. As an example of this further technique the heating of zinc acetate and glycerol forms a zinc glycerolate complex via a solution phase.
APPLICATION OF THE INVENTION
Research has shown that when zinc oxide is reacted with glycerol a reaction product results which either by itself or in combination with other substances is higly suitable as a pharmaceutical compound, particularly where high lubricity is required, the compound when examined by electron microscopy is shown to consist of crystals which can be of varying size which, by correct preparation, can range from large hexagonal crystals through a range of sizes to relatively small hexagonal crystals, the crystals according to the preferred formulation being in the nature of platlets of relatively low thickness and with low friction characteristics between the platlets so that the platlets slide readily one over the other to provide a thin but effective covering on a surface being treated. Because of the lubricity of the crystals they can move over each other freely to provide a required coverage, this being aided by the large variation in size of the relatively thin platlets so that smaller crystals fit into the spaces between larger crystals and provide a highly successful protective screen.
In the d
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patent: 4316852 (1982-02-01), Blackford
Taylor et al., Australian Journal of Chemistry, (1970), vol. 23, pp. 1963-1971.
Brock Alan J.
Taylor Reginald M.
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