Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-

Details Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1- Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-

1992-08-04

1993-06-22

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548207, A61K 3142, C07D51310

Patent

active

052216861

ABSTRACT:
This invention relates to novel spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides characterized by the general formula (I), ##STR1## wherein R is lower alkyl containing 1 to 6 carbon atoms, cycloalkyl containing 5 to 6 carbon atoms, allyl, benzyl, halogen substituted benzyl, aralkyl containing 7 to 10 carbon atoms, halogen substituted aralkyl containing 7 to 10 carbon atoms; 3-phenyl-2-propynyl and halogen substituted 3-phenyl-2-propynyl and the pharmaceutically acceptable salts thereof, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical compositions thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated diabetic complications.

REFERENCES:
patent: 4226875 (1980-10-01), Schnur
patent: 4864028 (1989-09-01), York
patent: 4900739 (1990-02-01), Wrobel
patent: 4927831 (1990-05-01), Malamas
patent: 4980357 (1990-12-01), Goldstein et al.

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