Diaminopyridine compounds and methods of use

Details Diaminopyridine compounds and methods of use Diaminopyridine compounds and methods of use

1992-01-17

1993-06-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514345, 514348, 514349, 424 54, A61K 3144, A61K 722

Patent

active

052216837

ABSTRACT:
The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 4386095 (1983-05-01), Gibson et al.
McEvoy et al., New England J. of Med., 321(23), pp. 1567-1571 (1989), "3,4-Diaminopyridine in the Treatment of Lambert-Eaton Myasthenic Syndrome."
Bever Jr., et al., Annals of Neur., 27(4), pp. 421-427 (1990), "Preliminary Trial of 3,4-Diaminopyridine in Patients with Multiple Sclerosis."

Affiliated with

Also associated with

Rating

Diaminopyridine compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaminopyridine compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaminopyridine compounds and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1441215