Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-02-11
1986-04-15
Chan, Nicky
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549426, 549427, 549396, 549338, 549337, 536122, C07D31194, C07D30906
Patent
active
045829160
ABSTRACT:
Sulfamates of the following formula (I): ##STR1## wherein X is O or CH.sub.2 and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.
REFERENCES:
patent: 4075351 (1978-02-01), Hirsch
Hedayatullah et al., Tet. Lett., No. 29, pp. 2455-2458, 1975.
N. K. Kochetkov, et al. in Zhurnal Obshchei Khimii, vol. 41, No. 8, pp. 1866-1871, (1971).
N. K. Kochetkov, et al. in Journal of General Chemistry of the USSR 42 (12), 2755-2757, (1972); and 44 (4) 871-875 (1974).
N. K. Kochetkov, et al. in Doklady Akademii Nauk SSSR, vol. 216, No. 1, pp. 97-100, (1974).
Tetrahedron Letters, No. 36, pp. 3365-3368, Pergamon Press Ltd., (1978), by T. Tsuchiya.
J. Med. Chem., 1981, 24, 901-903, A. F. Hirsch.
Gardocki Joseph F.
Maryanoff Bruce E.
Chan Nicky
Levy David J.
McNeilab Inc.
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