Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyri

Details Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyri Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyri

1984-11-16

1986-04-15

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 49, 514222, A61K 3154, C07D27902

Patent

active

045828318

ABSTRACT:
A novel crystalline form of the monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide has been prepared. This novel crystalline form is designated as polymorph I and is useful in therapy as a non-steroidal anti-arthritic agent. Methods for preparing this polymorph from readily available materials are provided.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino
patent: 4434164 (1984-02-01), Lombardino
J. G. Lombardino et al., "Potent Antiinflammatory N-Heterocyclic 3-Carboxamides of 4-Hydroxy-2-Methyl-2H-1,-2H-1,2-2-Benzothiazine 1,1-Dioxide", Journal of Medicinal Chemistry, vol. 16, No. 5, p. 493, (1973).

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