Process for preparing arylalkanoic acid derivatives

Details Process for preparing arylalkanoic acid derivatives Process for preparing arylalkanoic acid derivatives

1976-06-16

1978-08-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 56, 560100, 560102, 560105, 260515R, 260592, 2604482P, 260612D, 260613B, 260520R, 260520D, C07C 6976, C07C 6500, C07C 6352

Patent

active

041074394

ABSTRACT:
2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.

REFERENCES:
mcKillop, A. et al., JACS 95, pp. 3340-3343, 1973.

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