Bis-hydroxymethyl carbonate bridged antibacterial agents

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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Details

2602391, 2602452R, A61K 3143, C07D49932

Patent

active

043594727

ABSTRACT:
Antibacterial agents in which a penicillin and a beta-lactamase inhibitor are linked by means of a bis-hydroxymethyl carbonate bridge are of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 is hydrogen, hydroxy, certain acyloxy or certain alkoxycarbonyloxy groups, a method for their use, pharmaceutical compositions thereof, and intermediates useful in their production.

REFERENCES:
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patent: 3192198 (1965-06-01), Naylor et al.
patent: 3520876 (1970-07-01), Alburn et al.
patent: 3928595 (1975-12-01), Dahlen et al.
patent: 4053360 (1977-10-01), Bouzard
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham

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