Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1984-01-09
1990-01-09
Rosenbaum, C. Fred
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 93, 604288, 424426, A61B 1718
Patent
active
048925160
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a surgical aid which contains pharmaceutical active compounds in support materials which permit protracted release of the active compounds.
2. Technical Considerations and Prior Art
Agents which contain antibiotics and are used as surgical materials for controlling infections have been disclosed in German Patent Specification No. 2,320,373. They are used for, for example, in filling osteomyelitic cavities and are used in the form of beads which are connected together by means of threads or wires. These beads, which are produced from a material which is not absorbable by the body, must subsequently be surgically removed from the wound and thus cannot be advantageously used for managing infections of soft tissues. In addition, it is only possible with great difficulty to chieve uniform distribution of the beads over a relatively large wound area.
The use of partially absorbable multicomponent compositions which are based on physiologically tolerated substances and contain medicaments and which are intended to serve as a permanent replacement for bone and, with this object, are completely integrated into the biological system, without there being the necessity for later reoperation to remove the implant, are known from German Specification No. 2,917,037. This composition, which takes the form of granules or a moulded composition, cannot be used for managing normal wounds since integration into the bone is impossible in this instance.
SUMMARY OF THE INVENTION
Thus, an object of this invention was to find a surgical aid which is suitable for absorbing and releasing, in a protracted manner, medical active compounds and which, in particular, can also be used for normal wounds.
Another object was to design the agent such that uniting the tissue in the surfaces of the wound can take place as far as possible uninhindered, without the surgical aid which is used interfering with this reuniting or there being a necessity for its later removal.
Finally, still another object was to design the agent such that it permits medical active compounds to be placed so as to act at sites which can be accurately determined beforehand, for example in a uniform distribution over the entire wound area, or specifically localised at one or more points.
This object has been achieved by the present invention.
Thus the invention relates to a surgical aid, which contains pharmaceutical active compounds in support materials which permit protracted release of the active compounds, and which is characterised in that it is designed in the form of a flat article provided with free spaces, as a rule the individual free spaces having, at least predominantly, an area of at least 0.1 cm.sup.2.
A significant advantage of the aids according to the invention is that medical active compounds can be introduced into the body at defined spacings from one another and thus in an exactly defined spatial distribution, and can display their actions at sites in the body which can be accurately determined beforehand. Direct contact with the surfaces of the wound, and thus healing without difficulty and without the formation of scar tissue, is made possible by the flat design of the aid and the high proportion of free spaces. The aids can be designed in the form of, for example, lattices or perforated plates which have free spaces which are sufficiently large for the tissue in the surfaces of the wound to unite.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a top planar view a first embodiment of the surgical aid of the instant invention, wherein the surgical aid is configured as a lattice with medicated beads disposed at points of intersection of the threads comprising the lattice;
FIG. 2 is a side view, in section, showing the lattice of FIG. 1 implanted in a wound, wherein the lattice itself is shown in section taken along line II--II of FIG. 1;
FIG. 3 is a top view of another embodiment of the instant invention wherein the surgical aid is configured as a perforated plate;
FIG.
REFERENCES:
patent: 3882858 (1975-05-01), Klemm
patent: 4066083 (1978-01-01), Ries
patent: 4186448 (1980-02-01), Brekke
patent: 4329185 (1982-05-01), Dimer et al.
patent: 4510924 (1985-04-01), Gray
Merck Patent Gesellschaft mit beschrankter Haftung
Rosenbaum C. Fred
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