Treatment of diabetic complications with certain spiro-imidazoli

Details Treatment of diabetic complications with certain spiro-imidazoli Treatment of diabetic complications with certain spiro-imidazoli

1984-02-07

1985-09-10

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514389, 514866, A61K 31415, A61K 31435

Patent

active

045407002

ABSTRACT:
Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.

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