Dopamine agonists and use thereof

Details Dopamine agonists and use thereof Dopamine agonists and use thereof

1984-04-13

1985-09-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602444, 2603303, 2603307, 2602433, 514230, 514232, 514234, 514236, 514237, 514239, 544101, 544 73, A61K 31535, A61K 3155, C07D26536, C07D26714

Patent

active

045406910

ABSTRACT:
Compounds are disclosed having the formula: ##STR1## wherein: R.sub.1 is H, OH, --OCH.sub.3, --CH.sub.2 OH, --NH.sub.2, --NHMe, --NHEt, --NMe.sub.2, --NEt.sub.2, ##STR2## R.sub.2 is H, --CH.sub.3, or ##STR3## R.sub.3 is phenyl, benzyl, or 1-4 carbon alkyl; R.sub.4 is H, --CH.sub.3, --CH.sub.2 OH, --CH.sub.2 --CN, --CH.sub.2 --S--Me, CH.sub.2 --S--CN, or ##STR4## R.sub.5 is H, 1-4 carbon alkyl, alkenyl, or alkynyl, or aralkyl having a 1-4 carbon alkylene moiety; and A is --CH.sub.2 --or --CH.sub.2 CH.sub.2 --, and pharmaceutically-acceptable salts thereof. Pharmaceutical preparations using these compounds and a method for inducing a dopaminergic response by administering these compounds are also disclosed.

REFERENCES:
patent: 4420480 (1983-12-01), Jones
Perrone, R. et al., Synthesis of Naphtho- and Indeno [1,4] Oxazines, A New Class of Rigid Dopamine Congeners, 1984, II Farmaco 39, 255.
Cannon, J. G., et al.; Rigid Congeners of Dopamine Based On Octahydrobenzol[f]quinoline: Pheripheral and Central Effects; Journal of Medicinal Chemistry, 1979, vol. 22, No. 4, 341-346.
Wikstrom, H., et al.; Monophenolic Octahydrobenzol[f]quinolines: Central Dopamine- and Serotonin-Receptor Stimulating Activity; J. Med. Chem. 1982, 25, 925-931.

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