Thioformamide derivatives and use in inhibiting gastric secretio

Details Thioformamide derivatives and use in inhibiting gastric secretio Thioformamide derivatives and use in inhibiting gastric secretio

1985-11-18

1987-07-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, 546268, 514342, C07D40900, C07D40100, A61K 3144

Patent

active

046803033

ABSTRACT:
Thioformamide derivatives of formula: ##STR1## in which R is hydrogen or alkyl (1 to 4 C), R.sub.1 is alkyl (1 to 4 C), and X denotes sulphur or oxygen and Y is sulphur, oxygen, methylene radical, or, when X is oxygen, a valency bond, are inhibitors of gastric secretion and therefore useful in the treatment of gastric ulcers. They may be made by reaction of an amine R--NH.sub.2 with a corresponding thioester or, when R is alkyl, by reaction of an alkyl isothiocyanate with the product of reacting a base with a compound of formula: ##STR2##

REFERENCES:
patent: 4379154 (1983-04-01), Aloup et al.

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