1-alkyl-3-hydroxy-3-phenylpiperidines

Details 1-alkyl-3-hydroxy-3-phenylpiperidines 1-alkyl-3-hydroxy-3-phenylpiperidines

1986-01-29

1987-07-14

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546216, C07D21142, A61K 31445

Patent

active

046803025

ABSTRACT:
The present invention relates to 1-alkyl-3-hydroxy-3-phenylpiperidine derivatives of the formula ##STR1## wherein R is a C.sub.2 -C.sub.4 alkyl group, and their addition salts. These derivatives are useful as pharmaceuticals, especially as CNS-antidepressants.
They can be prepared in accordance with the following reaction (wherein X is a halogen atom and R is defined as indicated above): ##STR2##

REFERENCES:
patent: 2589943 (1952-03-01), Jensen
patent: 4263438 (1981-04-01), Althuis et al.
patent: 4382942 (1983-05-01), Nedelec et al.
M. A. Iorio et al, Tetrahedron, vol. 26 (1970), pp. 5519-5527.
Aldo Balsamo et al, Eur. J. Med. Chem.-Chimica Therapeutica, Mar.-Apr., 1981, vol. 16(2), pp. 163-169.
Uli Hacksell et al, J. Med. Chem. (1981) vol. 24, pp. 1475-1482.
B. A. Hemsworth et al, J. Pharm. Pharmacol. (1975), vol. 27, Suppl. 64P.
H. W. Bersch et al, Tetrahedron Letters, No. 11 (1966), pp. 1141-1144.
R. V. Stevens et al, Jour. Chem. Soc., Chem. Commun., (1975) No. 16, p. 682.

Affiliated with

Also associated with

Rating

1-alkyl-3-hydroxy-3-phenylpiperidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-alkyl-3-hydroxy-3-phenylpiperidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-alkyl-3-hydroxy-3-phenylpiperidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1427821