Porous ceramic carriers for controlled release of proteins, poly

Details Porous ceramic carriers for controlled release of proteins, poly Porous ceramic carriers for controlled release of proteins, poly

1978-09-12

1980-08-19

McCarthy, Helen M.

Compositions: coating or plastic

Coating or plastic compositions

Metal-depositing composition or substrate-sensitizing...

106 733, 106 7333, 106 734, 106 735, 128260, 424 19, A61M 700, C04B 3324, C04B 3544

Patent

active

042182557

ABSTRACT:
The product and process of making an in-vivo body implant pharmaceutical carrier of a resorbable ceramic crystalline structure of interconnecting pores capable of the critical controlled time release of pharmaceutical preparations such as proteins, polypeptides, hormones, and other small molecular weight active materials. The ceramic is comprised of aluminum oxide (Al.sub.2 O.sub.3), calcium oxide (CaO), and phosphorous pentoxide (P.sub.2 O.sub.5) in a controlled weight percent mixture. In the process of making, the mixture is calcined. The calcined mixture is again ground and sieved through screens of two different mesh sizes to obtain desired sizes and mixed with a binder. This mixture is compressed and sintered at a predetermined temperature. The particle sizes of the sieved calcined compound and the sintering temperatures are interrelated to provide a ceramic of a desired pore size for the controlled release of the pharmaceutical.

REFERENCES:
patent: 2021520 (1935-11-01), Reichmann
patent: 3288615 (1966-11-01), Estes et al.
patent: 3919723 (1975-11-01), Heimke et al.
patent: 4135935 (1979-01-01), Pfeil et al.
Graves, G. A. et al. "The Influence of Compositional Variations on Bone Ingrowth of Implanted Porous Calcium Aluminate Ceramics", J. Biomed. Mater Res. Symposium No. 6 (pp. 17-22) Jul. 1975.
Chem. Abstracts 76, (1972) item 30904j.
Chem. Abstracts 76, (1972) item 30905k.

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