Piperidine compounds and pharmaceutical uses thereof

Details Piperidine compounds and pharmaceutical uses thereof Piperidine compounds and pharmaceutical uses thereof

1988-05-24

1989-11-21

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514213, 540491, 540523, 546248, 546246, 546241, 546233, 546229, A61K 3155, C07D28102

Patent

active

048823260

ABSTRACT:
Piperidine compounds of the formula: ##STR1## or isomers thereof as well as pharmaceutically acceptable salts and/or hydrate forms thereof, and piperidine compounds of the formula: ##STR2## or isomers thereof as well as salt and/or hydrate forms thereof. In the above formulae, A represents a methylene group, an oxygen atom or a sulfur atom; B represents an oxygen atom or a sulfur atom; R.sup.1 and R.sup.2 independently represent a hydrogen atom, a lower alkyl group or an aralkyl group; R.sup.3 represents a hydrogen atom or an amino protecting group; Z represents an amino group or a protected amino group, a hydroxy group, or a reactive atom or group; m represents 1 or 2; and n represents the integer of 0 to 3.
Piperidine compounds (I) possess an inhibitory activity against angiotensin-converting enzyme, and exhibit a long lasting hypotensive activity and are useful as antihypertensive agents. Piperidine compounds (II) are useful as intermediates for said piperidine compounds (I).

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4477464 (1984-10-01), Slade et al.
patent: 4548932 (1985-10-01), Sugihara et al.
patent: 4564612 (1986-01-01), Sugihara et al.
patent: 4638000 (1987-01-01), Sugihara et al.
Derwent Publications Ltd., J61148-171-A & EP 72-352, Drugs of the Future, vol. 8, No. 12, 1983, p. 1051.

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