Biheteroaryl inhibitors of farnesyl-protein transferase

Details Biheteroaryl inhibitors of farnesyl-protein transferase Biheteroaryl inhibitors of farnesyl-protein transferase

1997-03-27

1998-12-29

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514342, 5462727, 5462751, C07D40114, C07D40514, C07D40714, A61K 31415, A61K 31455

Patent

active

058542655

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 4581369 (1986-04-01), Tsuruda et al.
patent: 4652572 (1987-03-01), Jones et al.
patent: 4713387 (1987-12-01), Watanabe et al.
patent: 5021434 (1991-06-01), Strehlke et al.
patent: 5478934 (1995-12-01), Yuan et al.
patent: 5587390 (1996-12-01), Salimbeni et al.

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