Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhy

Details Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhy Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhy

1980-03-10

1986-04-29

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548541, A61K 3140, C07D20712

Patent

active

045857857

ABSTRACT:
Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.

REFERENCES:
patent: 3577432 (1971-05-01), Helsey et al.
patent: 4252809 (1984-06-01), Walsh et al.
patent: 4320137 (1982-03-01), Paioni
Burger (ed.) Med. Chem., pp. 42+497, 2nd ed., Intersci. (1960).

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