Pyrrole-2-acetylamino acid derivative compounds

Details Pyrrole-2-acetylamino acid derivative compounds Pyrrole-2-acetylamino acid derivative compounds

1983-01-26

1986-04-29

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548539, A61K 3140, C07D207333

Patent

active

045857849

ABSTRACT:
Novel pyrrole-2-acetylamino compounds of the formula: ##STR1## and salts thereof, wherein R" is H, alkyl, (CH.sub.2).sub.n CO.sub.2 H, CH.sub.2 CH.sub.2 SCH.sub.3, (CH.sub.2).sub.4 NH.sub.2 or (CH.sub.2).sub.2 CONH.sub.2 ; and n is 1 or 2, which have the same analgesic and antiinflammatory utility as zomepirac, but with reduced liability toward gastrointestinal irritation, and esters of the compounds of the above formula which are useful as intermediates to make said compounds.

REFERENCES:
patent: 3336194 (1967-08-01), Shen
patent: 3752826 (1973-08-01), Carson
patent: 3962471 (1976-06-01), Biere et al.
patent: 4379793 (1983-04-01), Badia et al.
patent: 4396626 (1983-08-01), Ward et al.
patent: 4434175 (1984-02-01), Doherty et al.
Massaroli, UK patent application, 12-1-82, G.B. 2,098,989 A, 3 pages.
Burger, Medicinal Chemistry, 3rd ed., Part I, (1970), pp. 50-59, Wiley-Interscience, N.Y.
Abstract of JA-7244221-R (Sumitomo Chem. Co. Ltd.), 8-11-72.

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