Method for measuring the radioactivity of samples and an apparat

Details Method for measuring the radioactivity of samples and an apparat Method for measuring the radioactivity of samples and an apparat

1990-05-07

1991-08-27

Fields, Carolyn E.

Radiant energy

Automatic/serial detection of similar sources

422102, G01T 702

Patent

active

050435817

ABSTRACT:
The invention relates to a method and an apparatus for measuring the radioactivity of samples that are arranged in the wells of a microtitre plate and in which the radio-activity is solid-bound, for example cell-bound, or is in the form of a protein precipitate, wherein samples suspended, dissolved or mixed in liquids are first separated from the liquids and then their liquid supernatant is removed by suction. The invention comprises connecting the bases (4) of the wells of the microtitre plate to one another and then separating them from the microtitre plate or the well walls in such a manner that they remain connected, and subsequently measuring the samples they carry in succession, in groups or simultaneously over the entire grid. Thus, the well bases (4) can be handled and prepared for the measurement of radioactivity in their original position and arrangement even after separation from the rest of the microtitre plate, it being possible to bring the bases (4), which have been separated from the microtitre plate, and the samples arranged thereon close to, and within touching distance of, the measuring apparatus. As a result, a high degree of sensitivity and spatial resolution can be achieved, even in the case of samples of which the emitted electron radiation has only a very small range.

REFERENCES:
patent: 3924128 (1975-12-01), Frank
patent: 4065383 (1977-12-01), Skare et al.
patent: 4119850 (1978-10-01), Reddy et al.
patent: 4292273 (1981-09-01), Butz et al.
patent: 4752557 (1988-06-01), Tsuchino et al.

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