Prazosin analog with increased selectivity and duration of actio

Details Prazosin analog with increased selectivity and duration of actio Prazosin analog with increased selectivity and duration of actio

1987-12-31

1992-05-05

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40304

Patent

active

051109271

ABSTRACT:
Alkylating analogs of prazosin were synthesized and found to compete with nanomolar potency at .sup.3 H-prazosin binding sites of rat tissues. The compounds were found to be irreversible ligands at .sup.3 H-prazosin binding sites, and denoted a subtype of alpha.sub.1 -adrenoceptors.

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