Taxol treatment of breast cancer

Details Taxol treatment of breast cancer Taxol treatment of breast cancer

1994-01-06

1996-03-05

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31335

Patent

active

054968461

ABSTRACT:
The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having breast cancer using the microtubule agent, Taxol. The present method of administration, serves to prevent or retard the adverse side effects associated with Taxol and reduces the chances of a patient developing mdr Taxol resistance. The novel method of treatment provides a low-dose, longterm exposure to Taxol in a patient.

REFERENCES:
Holmes, F. A., et al., "Phase II Trail of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer", J. Natl. Cancer Inst., 83, No. 24, 1797-1805 (Dec. 18, 1991).
Extra, J. M., et al., "Phase I Trial of Taxotere", Proc. Am. Assoc. Cancer Res. Annu. Meet., 32, 205, (Mar. 1991).
Schmid, S. M., et al., "IFN 6 Augmentation of Taxol Anticellular Effect: Comparison with Taxol/Cisplatin or Taxol/Adriamycin in MCF-7 Breast Carcinoma Cells", J. Interferon Res. 11 (Suppl. 1) S237 (1991).
Fojo, A. T., et al., "Expression of A Multidrug-Resistance Gene in Human Tumors and Tissues", Proc. Natl. Acad. Sci. USA 84, 265-269, (Jan. 1987).
Rowinsky et al., Cancer Research, vol. 49, No. 16, pp. 4640-4647, Aug. 15, 1989.

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