Ophthalmic NSAID formulations containing a quaternary ammonium p

Details Ophthalmic NSAID formulations containing a quaternary ammonium p Ophthalmic NSAID formulations containing a quaternary ammonium p

1990-12-07

1992-05-05

Clingman, A. Lionel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

252106, 514912, 514914, A61K 3140

Patent

active

051104938

ABSTRACT:
Stable, clear, antimicrobially effective, ophthalmic formulations include an ophthalmologically effective amount of a drug, especially a --COOH group-containing drug or a NSAID, and a preservative system formed of a quaternary ammonium preservative and a nonionic surfactant, all in an aqueous vehicle. These formulations are useful for treating diseases that are either caused by, associated with or accompanied by inflammatory processes, including, among others, glaucoma, cystoid macular edema, uveitis, diabetic retinopathy and conjunctivitis, or any trauma caused by eye surgery or eye injury.

REFERENCES:
patent: 4087538 (1978-05-01), Portnoff
patent: 4087539 (1978-02-01), Muchowski et al.
patent: 4089969 (1978-03-01), Muchowski et al.
patent: 4097579 (1978-05-01), Muchowski et al.
patent: 4230724 (1980-10-01), Cooper et al.
patent: 4232038 (1980-08-01), Kluge et al.
patent: 4336151 (1982-03-01), Like et al.
patent: 4336152 (1982-03-01), Like et al.
patent: 4454151 (1984-02-01), Waterbury
patent: 4474751 (1984-10-01), Haslam et al.
patent: 4474811 (1984-10-01), Masuda et al.
patent: 4500538 (1985-02-01), Woltersdorf
patent: 4559343 (1985-12-01), Han et al.
patent: 4607038 (1986-08-01), Ogata et al.
Fraser-Smith et al., "Effect of Ketorolac on Pseudomonas aeruginosa . . . "; J. Ocular Pharmacol., v 4(2), pp. 101-109 (1988).
"Influence of (Ethoxy).sub.5 Octyl Phenol on the Antibacterial Properties of Preservatives", M. T. Nadir, et al., Journal of Pharmacy and Pharmacology, vol. 29, Supplement, Dec. 1977, p. 67P.
"Ocufen (flurbiprofen sodium) 0.03% Liquifilm sterile ophthalmic solution," Allergan, product description sheet, one page.
CTFA Cosmetic Ingredient Dictionary; Cosmetic, Toiletry and Fragrance Association, Inc., pp. 187-188.
Schmolka, Irving R., "The Synergistic Effects of Nonionic Surfactants Upon Cationic Germicidal Agents", J. Soc. Cosmet. Chem. 24, 577-592 (Aug. 9, 1973).
The Condensed Chemical Dictionary, Seventh Ed., Reinhold Publishing Co., N.Y. p. 985.
McCutcheon's, "Emulsifiers & Detergents," North American Edition, 1982, p. 154.

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