Biphenyl substituted dipeptide analogs promote release of growth

Details Biphenyl substituted dipeptide analogs promote release of growth Biphenyl substituted dipeptide analogs promote release of growth

1995-08-01

1998-03-10

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514 19, 5142358, 546348, 549 29, 549 49, 549462, 549505, 548146, 548215, 548250, 548255, 548262, 5483351, 5483611, 548400, 548484, C07D25700, A61K 3800

Patent

active

057263191

ABSTRACT:
There are disclosed certain compounds identified as substituted dipeptide analogs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such substituted dipeptide analogs as the active ingredient thereof are also disclosed.

REFERENCES:
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patent: 5206235 (1993-04-01), Fisher et al.
Fujii, et al., Chem. Pharm. Bull., 32(3), 1200-1208 (1994), "Synthesis of Growth Hormone Releasing Factor (GRF-37-NH2) and Nalpha-Biotinyl-GRF-44-NH2".
Sato, et al., Int. J. Peptide Protein Res., 38, 340-345 (1991), "Solid Phase Synthesis of Human Growth Hormone-Releasing Factor Analogs Containing a Bicyclic Beta-turn Dipeptide".
Merck Manual of Diagnosis and Therapy, Fifteenth Ed, 950-955 (1987).
Rudinger, Peptides Hormones (Ed. J. Parsons, University Park Press, Jun. 1976) pp. 1-7.
Melmon et al. "Drug Interactions" Goodman & Gilman, The Pharmacological Basis of Therapeutics 6th Ed (MacMillan Publishing 1980) pp. 1738-1740.
Meier et al. J. Org. Chem. vol. 56 No. 18 (Aug. 1991) pp. 5380-5384.

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