Process for chloronitroacetic acid esters

Details Process for chloronitroacetic acid esters Process for chloronitroacetic acid esters

1993-09-09

1995-03-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur halides

C07D20934

Patent

active

053959639

ABSTRACT:
A process for the production of 5-chloroxindole starting from chloronitrobenzene. In this way, in a first step, chloronitrobenzene of the formula: ##STR1## is converted with a chloro acetic acid alkyl ester of the general formula: ##STR2## in the presence of a base to a chloronitrobenzene acetic acid alkyl ester of the general formula: ##STR3## The latter is catalytically hydrogenated in a second step with hydrogen to the corresponding amine of the general formula: ##STR4## The latter is then cyclized in a third step in the presence of an acid to the end product according to the formula: ##STR5##

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