Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for t

Details Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for t Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for t

1993-11-30

1995-03-07

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558 44, 558 61, 558 62, 558159, A61K 3166, C08F 940

Patent

active

053958268

ABSTRACT:
Compounds of the tautomeric formula Ia, Ib or Ic, ##STR1## where R is a radical of the formula ##STR2## are effective compounds for the treatment and prophylaxis of degenerative bone disorders. They are used as pharmaceuticals.

REFERENCES:
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patent: 4927814 (1990-05-01), Gall et al.
patent: 4942157 (1990-07-01), Gall et al.
patent: 5294608 (1994-03-01), Lang et al.
Abstract of Isomura et al., Heterocycle-Substituted Bis(phosphonic acid) Derivatives and Bone Absorption Inhibitors Containing Them, Chemical Abstracts, 113(9):812, 78695b (1990).
"New Methods of Preparative Organic Chemistry IV. Synthesis Using Heterocyclic Amides (Azolides)", Staab, H. A., Angew. Chem. internat. Edit. 1(7):351-367 (1962).
Advanced Organic Chemistry-Reactions, Mechanisms, and Structure, Mar. J., Fourth Edition, pp. 348-352.
"Zur Guanylierung von Aminen mit O-Methyl-isoharnstoff-sulfat", Weiss et al., Chemiker-Zeitung, 98(12):617-621(1974).

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