Metal complexes for hypoxic cells

Details Metal complexes for hypoxic cells Metal complexes for hypoxic cells

1994-07-25

1996-04-09

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 10, 548106, 5483121, 5483275, 552294, 556 37, C07F 1300, C07F 506, C07F 900, C07D23391

Patent

active

055063454

ABSTRACT:
Agents for the diagnosis or treatment of hypoxic cells comprise a bioreductive moiety such as 2-nitroimidazole, and a metal chelating moiety which is a bis-amine oxime of which a carbon atom adjacent a nitrogen atom is linked to the bioreductive moiety. A chelated metal atom or ion preferably Technetium-99m. The agent diffuses into cells where the 2-nitroimidazole is reduced thus trapping the chelated metal in the cell.

REFERENCES:
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patent: 2704755 (1955-03-01), Kendall et al.
patent: 3576639 (1971-04-01), Jenkins
patent: 3641047 (1972-02-01), Beaman et al.
patent: 4550175 (1985-10-01), Mixich et al.
patent: 5036096 (1991-07-01), Suto
patent: 5110826 (1992-05-01), Hori et al.
patent: 5217986 (1993-06-01), Pomponi et al.
Journal of Medicinal Chemistry, 33(9), 2603-2610 (Sep. 1990), Jenkins et al.

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