Production of 2-hydroxy substituted arylalkanoic acids and ester

Details Production of 2-hydroxy substituted arylalkanoic acids and ester Production of 2-hydroxy substituted arylalkanoic acids and ester

1990-10-29

1991-10-29

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, 435136, 435874, C07C 7148, C12P 762, C12P 740

Patent

active

050616293

ABSTRACT:
Enantiomerically pure (2R)-2-hydroxy arylalkanoic acid esters and (2S)-2-hydroxy arylalkanoic acids are prepared by the Pseudomonas lipase-catalyzed selective hydrolyxis of racemic (2RS)-2-hydroxy arylalkanoic acid esters in solution or suspension in an aqueous medium at a controlled pH of from about 5 to about 9.

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Kitazume et al., J. Org. Chem., vol. 51, pp. 1003-1004 (1986).
Xie et al., J. Chem. Soc., Chem. Commun., pp. 838-839 (1987).
Iriuchijima et al., "Asymmetric Hydrolysis of (.+-.)-.alpha.-Substituted Carboxylic Acid Esters With Microorganisms," Agric. Biol. Chem., V45(6), 1389-1392, 1981.
Amano International Enzyme Co., Inc. Technical Bulletin, Lipase P.

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