Stabilized solid pharmaceutical preparation and method of produc

Details Stabilized solid pharmaceutical preparation and method of produc Stabilized solid pharmaceutical preparation and method of produc

1996-10-30

1998-03-10

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514289, 514568, 514849, A01N 4390, A61K 3133

Patent

active

057261806

ABSTRACT:
To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.

REFERENCES:
patent: 4049803 (1977-09-01), Cotty et al.
patent: 4420483 (1983-12-01), Sunshine et al.
patent: 4593026 (1986-06-01), Guinot
JP-67004062 Derwent Abstract 63:11-13.
Chemical Abstracts 109:156338 Yang et al.
Tan et al., Analytica Chimica Acta., vol. 226, No. 1, pp. 159-164 (1989).
Chugai Pharm. Co., Ltd. Database WP1, Week 6800 Derwent Pub. Ltd., GB AN67-08368g JP-B-42004062.

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