Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-19
1996-04-09
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142275, 5142312, 5142395, 514571, 514717, 514913, A61K 3155, A61K 31535, A61K 31075
Patent
active
055062261
ABSTRACT:
Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
REFERENCES:
patent: 3255241 (1966-06-01), Schultz et al.
patent: 3352904 (1967-11-01), Bicking et al.
patent: 3419606 (1968-12-01), Bicking et al.
patent: 4342782 (1982-08-01), Cragoe
patent: 4390537 (1983-06-01), Cragoe, Jr.
patent: 4699926 (1987-10-01), Abraham
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4731473 (1988-03-01), Abrahalam
patent: 4751244 (1988-06-01), Abraham
patent: 4757089 (1988-07-01), Epstein
patent: 5352702 (1994-10-01), Cyrlin
Davson, Hugh Physiology of the Eye, 5th Ed., pp. 117-122, Pergamon Press, (1990).
Leo, Albert J., "Methods of Calculating Partition Coefficients," Comprehensive Medicinal Chemistry: The Rational Design, Mechanistic Study & Therapeutic Applications of Chemical Compounds, vol. 4, #18.7, pp. 295-319, Pergamon Press (1990).
Mirrless, Margaret S., et al., "Direct Measurement of Octanol-Water Partition Coefficients by High-Pressure Liquid Chromatography," Journal of Medicinal Chemistry, vol. 19, No. 5, pp. 615-619, (1976).
Wang, Wei, et al., "Lipophilicity Influence on Conjunctival Drug Penetration in the Pigmented Rabbit: A Comparison with Corneal Penetration," Current Eye Research, vol. 10, No. 6, pp. 571-579, (1991).
Goto, S., et al., "Stability and Serum Albumin Binding of Diuretics in Aqueous Solution," Yakugaku Zasshi, vol. 98, pp. 236-240, (1978).
Abraham D. J., et al., "Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues," J. Med. Chem., vol. 32, pp. 2460-2467 (1989).
Epstein, D. L., et al., "N-Ethylmaleimide Increases the Facility of Aqueous Outflow of Excixed Monkey and Calf Eyes," Ivest. Opthalmol. Vis. Sci., vol. 22, pp. 752-756, (1982).
Epstein, D. L., et al., "Influence of Ethacrynic Acid on Outflow Facility in the Monkey and Calf Eye," Invest. Opthalmol. Vis. Sci., vol. 28, pp. 2067-2075, (1987).
ARVO 1988, No. 24, p. 84; Ozment, et al., "The Effect of Intracameral Ethacrynic Acid on Intraocular Pressure of Living Monkeys".
ARVO 1989, Nos. 68 and 70, p. 356: Patel, et al., "Interactions of Ethacrynic Acid and Other Sulfhydryl Agents with Proteins in the Calf Trabeuclar Meshwork"; Schroeder, et al., Ethacrynic Acid Induced Changes in Cytoskeletal Tubulin.
ARVO 1990, No. 1849, p. 376: Liang et al., "Ethylacrynic Acid Increases Facility of Outflow in the Human Eye In Vitro".
Alcon Laboratories Inc.
Brown Gregg C.
Dees Jos,e G.
Jones Dwayne C.
Mayo Michael C.
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