Pyridine anchors for HMG-CoA reductase inhibitors

Details Pyridine anchors for HMG-CoA reductase inhibitors Pyridine anchors for HMG-CoA reductase inhibitors

1995-03-07

1996-04-09

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 22, 546 23, C07F 958, C07F 960, A01N 4340, A01N 4342

Patent

active

055062199

ABSTRACT:
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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