Derivatives of thienylacetic acid amides and their pharmaceutica

Details Derivatives of thienylacetic acid amides and their pharmaceutica Derivatives of thienylacetic acid amides and their pharmaceutica

1983-11-22

1985-02-12

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546213, 549 76, C07C10382, A61K 3138

Patent

active

044992866

ABSTRACT:
Novel derivatives of thienylacetic acid amides of the general formula ##STR1## in which the two nitrogens on the cyclohexane ring are transconnected, the basic acetic acid amide radical is in position 2 or 3 of the thiophene nucleus, R is C.sub.1 -C.sub.3 alkyl, R.sub.1 and R.sub.2 are independently C.sub.1 -C.sub.3 -alkyl or represent together with the nitrogen atom to which they are attached a pyrrolidine or piperidine ring and X and Y are independently hydrogen, chlorine or bromine in position 2 to 5 of the thiophene nucleus in dependence on the position of the basic acetic acid amide group, and their pharmaceutically acceptable acid addition salts are .mu.-specific analgetics, which do not cause any physical dependence. Therefore, they are suitable for protracted treatment of pain conditions.

REFERENCES:
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4192885 (1980-03-01), Szmuszkovicz

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