Process for preparing 4-arylamino-benzopyran and related compoun

Details Process for preparing 4-arylamino-benzopyran and related compoun Process for preparing 4-arylamino-benzopyran and related compoun

1995-06-07

1997-05-13

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549399, 549404, C07D23302, C07D23304, C07D23354

Patent

active

056294298

ABSTRACT:
A method of preparing compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof which comprises converting a compound of the formula ##STR2## where the R.sup.2 substituent contains a hydrogen atom which is more acidic than the starred (*) hydrogen atom in formula II, to the corresponding dianion of formula ##STR3## where M is a counterion preferably lithium or magnesium, using two equivalents of a base in an inert solvent such as tetrahydrofuran; then reacting compounds of formula IIA with an epoxide of formula ##STR4## to produce the compounds of formula I.

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