Synthetic glycoamines that promote or inhibit cell adhesion

Details Synthetic glycoamines that promote or inhibit cell adhesion Synthetic glycoamines that promote or inhibit cell adhesion

1994-07-11

1997-05-13

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536115, 536119, 530322, A61K 3814, C07K 900, C07H 1302

Patent

active

056294123

ABSTRACT:
A class of molecules that alter cell adhesion. A cell adhesion affector according to the present invention essentially consists of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a compound chosen from the group consisting of Schiff bases, N-glycosides, esters, and Amadori products. The carbohydrate is preferably a monosaccharide or a small oligosaccharide. The carbohydrate and amino acid sub-units may be chemically modified. For example, the amino acid may be modified by covalently bonding other groups to the amino group, carboxyl group, or side chain group of the amino acid. The carbohydrate sub-unit is preferably a pentose such as arabinose, xylose, ribose, ribulose, a hexose such as fructose, deoxyfructose, galactose, glucose, mannose, tagatose, rhamnose, or a disaccharade based on two of the above such as maltose, lactose, maltulose, or lactulose.

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