Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Patent
1993-03-05
1997-01-14
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
424 9371, 530350, A61K 3514, A01N 6300, C07K 100, C07K 1400
Patent
active
055936989
ABSTRACT:
Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.
REFERENCES:
Benichou, et al, 1990, "Immunogenuity and tolero-genicity of . . . " J. Exp. Med. 172:1341-1346.
Sayegh, et al, 1992, "Induction of immunity and oral tolerance with . . . " PNAS 89:7762-7766.
Nuchtern et al., Nature, 343:74-76, 1990.
Parham et al., Nature, 325:625-628, 1987.
Chen et al., J. Exp. Med., 172:779-788, 1991.
Mowat, Immunology Today, 8:93-98, 1987.
Sayegh et al., Transplantation, 53(1):163-166, 1992.
Chao et al., Immunogenetics, 29:231-234, 1989.
Whitacre et al., J. Immunol., 147:2155-2163, 1991.
Nagler-Anderson et al., Proc. Natl. Acad. Sci. USA, 83:7443-7446, 1986.
Lider et al., J. Immunol., 142:748-752, 1989.
Miller et al., Proc. Natl. Acad. Sci. USA, 89:421-425, 1992.
Falk et al., Nature, 351:290-296, 1991.
Rudensky et al., Nature, 353:622-627, 1991.
Higgins, J. Immunol., 140:440-445, 1988.
Guillet, J. G. Science 235:865-70, Feb. 1987.
Zamvil, S. S. et al., Nature 324:258-60, Nov. 1986.
Wood, K. J. et al., Transplanation 39:56-62, No. 1, 1985.
Liu, Z. et al., J. Exp. Med. 175:1663-68, Jun. 1992.
Guillet, J. G. Nature 324:260-262, Nov. 1986.
Carpenter Charles B.
Hafler David A.
Sayegh Mohamed
Weiner Howard L.
Zhang Zhengyi
AutoImmune Inc.
Smith Lynette F.
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