Methods for treating gastro-esophageal reflux disease and other

Details Methods for treating gastro-esophageal reflux disease and other Methods for treating gastro-esophageal reflux disease and other

1993-10-12

1997-05-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

056293283

ABSTRACT:
Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is useful in treating emesis while substantially reducing adverse effects associated with racemic cisapride.

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patent: 5114714 (1992-05-01), Young et al.
patent: 5114715 (1992-05-01), Young et al.
Jamali, F., "Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls," Journal of Pharmaceutical Sciences 78(9): 695-715 (1989).
Dumuis et al., "The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT.sub.4) positively coupled to adenylate cyclase in neurons," Naunyn-Schmiedeberg's Arch Pharmacol 340: 430-410 (1989).
Scrip's New Product Review No. 32 Cisapride, PJB Publications Ltd. (Apr. 1989).
Barone et al., "Bioavailability of Three Oral Dosage Forms of Cisapride, a Gastrointestinal Stimulant Agent," Clincal Pharmacy 6: 640-645 (1987).
Stacher et al., "Effects of Oral Cisapride on Interdigestive Jejunal Motor Activity, Psychomotor Function, and Side-Effect Profile in Healthy Man," Digestive Disease and Sciences, 32(11): 1223-1230 (1987).
Nemeth et al, Chemical Abstracts, vol. 111, No. 19, abstract # 167161a, 1989.

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