Substituted cyclohexanol esters their use for treating diseases

Details Substituted cyclohexanol esters their use for treating diseases Substituted cyclohexanol esters their use for treating diseases

1996-07-19

1997-05-13

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 12, A61K 3154, C07D28524

Patent

active

056293119

ABSTRACT:
Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations
Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the meaning given herein. The compounds are pharmacologically active and my therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases which are characterized by an elevated secretion of glucose from the liver or by an elevated activity of the glucose-6-phosphatase system.

REFERENCES:
patent: 5463062 (1995-10-01), Hemmerle et al.
James Ashmore, et al., "The Role of Hepatic Glucose-6-phosphatase in the Regulation of Carbohydrate Metabolism", vol. XVII, 92-132 (1959).
Ann Burchell et al., "The Molecular Basis of the Hepatic Microsomal Glucose-6-phosphatase System", Biochem. Biophys. Acta 1092, 129-137 (1990).
James F. Soodsma et al., "The inhibition by Phlorizin of Kidney Microsomal Inorganic Pyrophosphate-Glucose Phosphotransferase and Glucose 6-Phosphatase", J. Biol. Chem. 242, 1955-1960 (1967).
Bruce K. Wallin et al., "The Requirement For Membrane Integrity In The Inhibition Of Hepatic Glucose 6-Phosphatase By Sulfhydryl Reagents And Taurocholate", Biochem. Biophys. Res. Commun. 48, 694-699 (1972).
Michael A. Zoccoli et al., "Effect of Two Inhibitors of Anion Transport On The Hydrolysis Of Glucose 6-Phosphate By Rat Liver Microsomes", J. Biol. Chem. 255, 1113-1119 (1980).
Wesley K. Canfield et al., "The Glucose-6-phosphatase System In Rat Hepatic Microsomes Displays Hyperbolic Kinetics At Physiological Glucose 6-phosphate Concentrations", J. Biol. Chem. 263, 7458-7460 (1988).
William J. Arion, "Measurments Of Intactness Of Rat Liver Endoplasmic Reticulum", Methods Enzymol., 174, Academic Press (1989), S.58-67.
J.C. Barriere et al., "Synthesis of Enantiomerically Pure Substituted Cyclopentenes From (-)-Quinic Acid", Helv. Chim. Acta 66, 269 (1983).

Affiliated with

Also associated with

Rating

Substituted cyclohexanol esters their use for treating diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted cyclohexanol esters their use for treating diseases , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted cyclohexanol esters their use for treating diseases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1385548