Inhibitors of TNF-.alpha. secretion

Details Inhibitors of TNF-.alpha. secretion Inhibitors of TNF-.alpha. secretion

1996-05-22

1997-05-13

Conrad, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 7, 514119, 514507, 514563, 530331, A61K 3800, A61K 3816, A61K 3166, A61K 31215

Patent

active

056292856

ABSTRACT:
Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biologically active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.

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