Phthalamide derivatives with anthelmintic activity

Details Phthalamide derivatives with anthelmintic activity Phthalamide derivatives with anthelmintic activity

1985-10-18

1987-09-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548245, A61K 3142, C07D26104

Patent

active

046940162

ABSTRACT:
Novel phthalamide compounds are disclosed having activity against a broad spectrum of parasitic worms and showing no toxicity to the host animal. These compounds are N-(3-chloro-4,5-dihydroisoxazol-4-yl)-N'-(substituted)phthalamides. A process for making these compounds and a method of administering them to animals are also disclosed.

REFERENCES:
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patent: 4322429 (1982-03-01), Burow
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patent: 4593024 (1986-06-01), Lu et al.
D. G. Martin et al., "The Isolation, Structure, and Absolute Configuration of U-42,126 a Novel Antitumor Antibiotic," Tetrahedron Letters No. 27, pp. 2549-2552 (1973).
Silverman & Holladay, "Stereospecific Total Syntheses of the Natural Antitumor Agent (Alpha S,5S)-Alpha-Amino-3-Chloro-4,5-Dihydro-5-Isoxazoleacetic Acid and its Unnatural C-5 Epimer," Journal of the American Chemical Society, 103, pp. 7357-7358 (1981).

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