Methods of concentrating ligands and active membranes used there

Details Methods of concentrating ligands and active membranes used there Methods of concentrating ligands and active membranes used there

1984-08-21

1987-09-15

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

2101982, 2104931, 21050038, 2105021, 210635, 435 13, 435180, 435181, 436532, 436548, 436824, 436827, 436828, B01D 1508, B01D 3900, G01N 33545

Patent

active

046939857

ABSTRACT:
A chemically active membrane having a large surface area is provided in which a hydrophilic, microporous, skinless, polyamide membrane is chemically bound to a residue of an activating agent which is capable of reacting with a biologically active material.
The chemically active membrane, formed by reacting a hydrophilic, microporous, skinless, polyamide membrane with an activating agent may be used to prepare a biologically active membrane having a large surface area which comprises an acceptor molecule such as a monoclonal antibody, a polyclonal antibody, an antigenic substance, a glycoprotein, Protein A, a lectin, a carbohydrate, an enzyme substrate, a cofactor, an inhibitor, a hormone, an IgG class of immunoglobulin, a carrier protein, a receptor, heparin, a coagulation factor, or a histone covalently bound to the hydrophilic, microporous, skinless, polyamide membrane by reacting the chemically activate membrane with the acceptor molecule.

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"Quantitative Removal of Hepatitis B Viral Antigens from Serum by a Monoclonal IgM Coupled to a Biocompatible Solid-Phase Support" by Marciniak et al, Proc. Natl. Acad. Sci. USA, 80, 3821-3825 (1983).

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