N-alkylation of amines

Details N-alkylation of amines N-alkylation of amines

1998-03-04

1999-06-29

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546184, 564479, C07D29502

Patent

active

059170395

ABSTRACT:
In a process for the N-alkylation of amines in which alcohols are reacted with alkylamines or dialkylamines in the presence of hydrogen, the reaction takes place on a catalyst based on copper and magnesium silicate and containing, in each case independently, 0 to 2% by weight of BaO, Cr.sub.2 O.sub.3 and/or ZnO. The amines employed are mono- or dimethylamine or mono- or diethylamine, the alcohols employed are .alpha.,.omega.-diols, in particular diethylene glycol or pentanediol. In particular there is reaction of diethylene glycol with monomethylamine and/or monoethylamine to give N-methylmorpholine and/or N-ethylmorpholine.

REFERENCES:
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patent: 4647664 (1987-03-01), Vanderpool et al.
patent: 4910304 (1990-03-01), Fischer et al.
patent: 5847131 (1998-12-01), Simon et al.
Chem. Abst., vol. 110, No. 9, Feb. 27, 1989 (HU 44479, Mar. 28, 1988).
Pat. Abst. of Japan, vol. 11, No. 163 (C-424), May 26, 1987 (JP 61 291551, Dec. 22, 1986).
Pat. Abst. of Japan, vol. 14, No. 485 (C-772), Oct. 23, 1990 (JP 02 202855, Aug. 10, 1990).
Pat. Abst. of Japan, vol. 2, No. 126 (C-025), Oct. 21, 1978 (JP 53 090227, Aug. 8, 1978).

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