Ureido amino and imino acids, compositions and methods for use

Details Ureido amino and imino acids, compositions and methods for use Ureido amino and imino acids, compositions and methods for use

1987-02-26

1990-01-02

Terapane, John F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20709

Patent

active

H00007250

ABSTRACT:
Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4604402 (1986-08-01), Godfrey, Jr. et al.
patent: 4621092 (1986-11-01), Natarajan et al.
Almquist et al., "Synthesis and Biological Activity . . . Angiotensin Converting Enzyme", J. Med. Chem., (1980), 23, pp. 1392-1398.
Almquist et al., "Synthesis and Biological Activity . . . 5(S)-Benzamido-4-oxo-6-phenylhexanoyl-L-proline", J. Med. Chem., 1985, 28, pp. 1062-1066, 1067-1071.

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