Method for treating liver injury

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, 530380, 530381, A61K 3800

Patent

active

059168749

ABSTRACT:
Disclosed is a method for treating liver injury caused by microorganism or toxic substance, which comprises administering to a patient suffering from liver injury a composition comprising a thrombomodulin, which has the ability to bind to thrombin and promote the activation of protein C by thrombin, as an active ingredient and at least one pharmaceutically acceptable carrier. The method of the present invention is very effective for ameliorating liver injury, such as fulminant hepatitis and hepatic veno-occlusive disease (VOD) which is likely to frequently occur after bone marrow transplantation.

REFERENCES:
Reeck et al Cell vol. 667, Aug. 1987.
Lewin et al Science 237:1570, 1987.
Zushi et al Journal Bio Chem 266:19886-19889, 1991.
Gomi et al Blood 75(7):1396-1399, 1990.
Robbins et al Pathologic Basis of Disease Third Edition:649-650, 1984.
Fukata Tokyo Jikeikai Medical Journal vol. 110 975-88, Abstract, 1995.
Chazouilleres et al J Gastroenterology and Hepatology vol. 10 471-480, 1995.
Epstein et al Transplantation vol. 54 (1) 12-16, 071992.
Brunetto et al FEMS Microbiological Reviews vol. 14 259-266, 1994.
Gomi, Komakazu, et al., "Antithrombotic Effect of Recombinant Human Thrombomodulin on Thrombin-Induced Thromboembolism in Mice" Blood, vol. 75, No. 7 (Apr. 91) (1990) pp. 1396-1399.
Suzuki, Koji, et. al. "Structure and Expression of Human Thrombomodulin, a Thrombin Receptor in Endothelium Acting as a Cofactor for Protein C Activation", EMBO Journal vol. 6, No. 7, (1987) pp. 1891-1897.
Esmon, Naomi L., et. al., "Isolation of a Membrane-bound Cofactor for Thrombin-catalyzed Activation of Protein C", J. Biol. Chem., 257, pp. 859-864 (1982).
Yamada, S., et. al., "Intravascular Coagulation in the Development of Massive Hepatic Necrosis Induced by Corynebacterium Parvum and Endotoxin in Rats", Scand J. Gastroen. erol., 24, pp. 293-298 (1989).
Yasunori Gonda, et. al., "Antithrombotic Efec of Recombinant Human Soluble Thrombomodulin on Endotoxin-induced Disseminated Intravascular Coagulation in Rats", Thrombosis Res., 71, pp. 325-335 (1993).
Michitaka Zuishi, et. al., "Aspartic Acid 349 in the Fourth Epidermal Growth Factor-like Structure of Human Thrombomodulin Plays a Role in its Ca.sup.2+ -Mediated Binding to Protein C.sup.* ", J. Biol. Chem., 266, 19886-19889 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for treating liver injury does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating liver injury, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating liver injury will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1375507

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.