IKK-.beta. proteins, nucleic acids and methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

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435194, C12P 148

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active

059167602

ABSTRACT:
The invention provides methods and compositions relating to an I.kappa.B kinase, IKK-.beta., and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-.beta. encoding nucleic acids or purified from human cells. The invention provides isolated IKK-.beta. hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-.beta. genes, IKK-.beta.-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
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Traenckner, E. B-M., et al. (1995) EMBO J. 14(2), 2878-2883.
DiDonato, J., et al. (1996) Mol. Cell. Biol. 16(4), 1295-1304.
Mock, B. A., et al. (1995) Genomics 27, 348-351.
Connelly, M.A., et al. (1995) Cell. Mol. Biol. Res. 41(6), 537-549.
Mercurio, F., et al. (1997) Science 278, 860-866.
Zandi, E., et al.(1997) Cell 91, 243-252.

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