Benzamide-containing pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514617, 514619, 514629, A61K 3116, A61K 31165

Patent

active

054729831

ABSTRACT:
A group of benzamide compounds are disclosed that are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from neurodegenerative conditions associated with dopamine depletion.

REFERENCES:
patent: 3883590 (1975-05-01), Schmerling
patent: 4994460 (1991-02-01), Dextraze et al.
Banasik et al., "Specific inhibitors of poly (ADP-Ribose) synthetase and mono(ADP-ribosyl) transferase" J. Biol. Chem. (1992) 267:1569-1575.
Bishop et al., "Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl-substituted benzamides: high-affinity ligands for CNS dopamine D.sub.2 receptors" J. Med. Chem. (1991) 34:1612-1624.
Burns, R. S., et al., in "A Primate Model of Parkinsonism . . . " Proc. Natl. Acad. Sci USA (1983) 4546-4550.
Communications to the Editor, "Evolution of a Novel Series of [(N,N-Dimethylamino)propyl]-and Piperazinylbenzanilides as the First Selective 5-HT.sub.ID Antagonists.sup.1 " Journal of Medical Chemistry (1994) 37:15, 2253-2255.
El Tayar et al., "Interaction of neuroleptic drugs with rat striatal D-1 and D-2 dopamine receptors: a quantitative structure--affinity relationship study" Eur. J. Med. Chem. (1988) 23:173-182.
Gerlach, M. et al., "MPTP Mechanisms of Neurotoxicity and the Implications for Parkinson's Disease" European Journal of Pharmacology (1991) 273-386.
Heikkila, R. E., et al., in "Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice" Science (Jun. 29, 1984) 224:1451-1453.
Hogberg et al., "Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[benzyl-2-pyrrolidinyl)methyl] benzamides. Relations to other side chain congeners" J. Med. Chem. (1991) 34:948-955.
Katopodis et al., "Novel substrates and inhibitors of peptidylglycine .alpha.-amidating monooxygenase" Biochemistry (1990) 29:4541-4548.
Langston J. W. et al., in "Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis" Science (Feb. 25, 1983), 219, 979-980.
Marsden, C. D., "Review Article--Parkinson's Disease" Lancet (Apr. 21, 1990) 948-952.
Monkovic et al., "Potential non-dopaminergic gastrointestinal prokinetic agents in the series of substituted benzamides" Eur. J. Med. Chem. (1989) 24:233-240.
Rainnie et al., "Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal" Science (1994) 263:689-690.
Singer, T. P., et al., "Biochemical Events in the Development of Parkinsonism . . . " J. Neurochem. (1987) 1-8.

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