Fluorenyl derivatives as anti-inflammatory agents

Details Fluorenyl derivatives as anti-inflammatory agents Fluorenyl derivatives as anti-inflammatory agents

1992-12-04

1995-12-05

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514480, 514567, 558240, 562433, 548251, 548253, C07D25704, C07C33308, C07C22942, A61K 31245, A61K 3141

Patent

active

054729734

ABSTRACT:
The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one compound represented by the formula.

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patent: 3919291 (1975-11-01), Toyoshima et al.
patent: 5079260 (1992-01-01), Weitzberg et al.
Rosenthale et al., "Immunopharmacologic Effects of Cycloleucine," In Journal of Pharmacology and Experimental Therapeutics, vol. 180, No. 2, pp. 501-513.
Ludwig et al., "MER-27, a Suppressant of Non-Bacterial Pneumonia in Mice," in Proc. Soc. Exp. Biol. Med., vol. 100, pp. 495-497 (1959).
Carpino, "The 9-Fluorenylmethyloxycarbonyl Family of Base-Sensitive Amino-Protecting Groups," in Accounts of Chemical Research, vol. 20, pp. 401-407 (1987).
Burch et al., in "N-(Fluorenyl-9-methoxycarbonyl) amino acids, a class of anti-inflammatory agents with a different mechanism of action," Proc. Natl. Acad. Sci. USA, vol. 88, pp. 355-359, Jan. 1991.

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