Process of making solid ribavirin dosage forms

Details Process of making solid ribavirin dosage forms Process of making solid ribavirin dosage forms

1997-12-22

1999-06-29

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424452, A61K 920, A61K 948

Patent

active

059165944

ABSTRACT:
A process of making an orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substantially free of polymorphic forms of ribavirin as determined is disclosed.

REFERENCES:
patent: 3424842 (1969-01-01), Nurnberg
patent: 3490742 (1970-01-01), Nichols et al.
patent: 3622677 (1971-11-01), Short et al.
patent: 4681765 (1987-07-01), Guley
patent: 4886669 (1989-12-01), Ventouras
patent: 5030447 (1991-07-01), Joshi et al.
patent: 5370878 (1994-12-01), Shah
patent: 5492692 (1996-02-01), Digenis et al.
patent: 5506248 (1996-04-01), Nikfar et al.
patent: 5605889 (1997-02-01), Curatolu et al.
patent: 5738872 (1998-04-01), Ortyl et al.
Prusiner et al Acta Crystallogr. B32(2):419-426 "Two Polymorphic Crystalline Forms of Virazole . . . ", (1976).
Prusiner et al Nature 244(134): 116-118 (Virazole, 2. Cryst. Polymorphs A & B), (1973).
Ding et al Zhongguo Linchuang Yaolixue Zazh1 10(3): 177-180 "Bioavailability of Ribavirin Capsules in Healthy Volunteers", (1994).
Magnussen et al Antimicrob. Agents Chemother. 12(4): 498-502 "Double Blind Evaluation of Oral Ribavirin (Virazole) in Exp. Influenza a Virus Infection in Volunteers",(1977).
Togo et al. Jl. Infect. Diseases 133 Suppl. A109-A103 Double Blind Clinical Assessment of Ribavirin (Virazole) in the Prevention of Induced Infection with Type B Influenza Virus, 1976.

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